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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1997-7-10
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pubmed:abstractText |
In the present study we examined the mechanism by which PAF activates MAPK in native cells such as guinea-pig neutrophils and P388D1 macrophage-like cells. We found that PAF activates MAPK through two distinct pathways. One calcium-dependent pathway that likely involves cPKC, and another calcium-independent but wortmannin-sensitive pathway. Using molecular biological methods we are presently examining whether hetrodimeric (p85/p110) type PI 3-kinase is the actual target of wortmannin involved in PAF mediated activation of MAPK.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
416
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
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pubmed:year |
1996
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pubmed:articleTitle |
PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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