Linked Life Data

9129991

Source:http://linkedlifedata.com/resource/pubmed/id/9129991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-7-24
pubmed:abstractText
As a part of host-defense immune system, macrophages can response to a variety of stimulants and produce superoxide. We examined the effect of adenosine as a modulator on superoxide production induced by phorbol ester in rat peritoneal macrophages, using an acetyl-cytochrome c reduction method for its detection. 2-Cl-adenosine, a least metabolizable analog of adenosine, inhibited the superoxide production in a dose-dependent manner, and also showed the increasing effect on intracellular cAMP level. Superoxide production was also inhibited by the several reagents which increased intracellular cAMP level, including dibutyryl-cAMP. 8-bromo-cAMP (cell permeable cAMP analogs), forskolin (an adenyl-cyclase activator). Ro 20-1724 (an phosphodiesterase inhibitor), and propentofylline (a xanthine derivative), but not 8-bromo-cGMP (cell permeable cGMP analog). These results suggest that a high level of extracellular adenosine may attenuate immunity through regulating macrophage functions. On the other hand, the tissue damage which is resulted from an over-production of superoxide can be protected by adenosine and its related drugs via an elevation of intracellular cAMP level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Adenosine inhibits superoxide production in rat peritoneal macrophages via elevation of cAMP level.
pubmed:affiliation
Department of Physiology, Ehime University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't