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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-7-18
|
| pubmed:abstractText |
Infusion of OT or the V1 agonist [Phe2,Orn8]-vasotocin (POVT) (50 ng) into the dorsal vagal complex of urethane-anaesthetized male rats induced a sustained hypertension. Simultaneous infusion of the V1 antagonist d(CH2)5[Tyr(Me)2]-VP blocked the effect of POVT, but not of OT. The OT antagonist d(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr-NH(9)2]-vasotocin blocked the effect of OT, but not of POVT. The OT agonist [Thr4,Gly7]-OT had no effect. This suggests that OT-induced hypertension involves mechanisms independent of V1 and uterine-type OT receptors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0168-0102
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-8
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:9129188-Animals,
pubmed-meshheading:9129188-Blood Pressure,
pubmed-meshheading:9129188-Drug Interactions,
pubmed-meshheading:9129188-Male,
pubmed-meshheading:9129188-Oxytocin,
pubmed-meshheading:9129188-Rats,
pubmed-meshheading:9129188-Rats, Wistar,
pubmed-meshheading:9129188-Vagus Nerve,
pubmed-meshheading:9129188-Vasopressins
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Evidence for independent hypertensive effects of oxytocin and vasopressin in the rat dorsal vagal complex.
|
| pubmed:affiliation |
Department of Anatomy, University of Bristol, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|