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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1977-12-29
|
| pubmed:abstractText |
An HGPRT- cell line derived from mouse L cells has been shown to have the following properties: it is CRM+; the defective HGPRT molecules are altered in the carboxyterminal peptide; the mutant cells regain HGPRT activity when ochre-suppressor tRNA is microinjected into them, but not when amber-suppressor or wild-type tRNAs are injected. We conclude from these properties that this mutant cell line contains an ochre nonsense mutation (UAA) in the structural gene for HGPRT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
371-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:912748-Cell Line,
pubmed-meshheading:912748-Genes,
pubmed-meshheading:912748-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:912748-Microinjections,
pubmed-meshheading:912748-Mutation,
pubmed-meshheading:912748-Peptides,
pubmed-meshheading:912748-RNA, Transfer,
pubmed-meshheading:912748-Suppression, Genetic
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
The isolation of a suppressible nonsense mutant in mammalian cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|