| pubmed-article:9127147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C0033085 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C1705182 | lld:lifeskim |
| pubmed-article:9127147 | lifeskim:mentions | umls-concept:C0442537 | lld:lifeskim |
| pubmed-article:9127147 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9127147 | pubmed:dateCreated | 1997-6-24 | lld:pubmed |
| pubmed-article:9127147 | pubmed:abstractText | We recently demonstrated that the peripheral gamma delta T-cell repertoire becomes oligoclonal with increasing age. Although this junctional homogeneity should not severely affect the ability of gamma delta T cells to respond to foreign antigens, we reasoned that a similar oligoclonal repertoire of alpha beta T cells would lead to a profound impairment of the MHC-restricted response. We used heteroduplex analysis in this research to study the clonal complexity of the peripheral alpha beta T-cell repertoire in human subjects and supply evidence for the presence of alpha beta clonal expansions. Clonal predominance in the alpha beta T-cell repertoire of normal subjects was not simply related to age, since the PBL of young donors also showed clonal expansions and did not always correlate with a numeric increase in the corresponding V beta family. However, the type of alpha beta expansion appears to be strikingly different from the gamma delta expansions. In the case of alpha beta T cells, even in the presence of clonal dominance, evidence for a residual polyclonal background was found in all the donors tested, irrespective of age. The observation that true oligoclonality is exceptionally rare among alpha beta T lymphocytes could mean that maintenance of a highly diversified reservoir of TCR is primary for these cells throughout life. | lld:pubmed |
| pubmed-article:9127147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9127147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9127147 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9127147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9127147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9127147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9127147 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9127147 | pubmed:issn | 0198-8859 | lld:pubmed |
| pubmed-article:9127147 | pubmed:author | pubmed-author:GiachinoCC | lld:pubmed |
| pubmed-article:9127147 | pubmed:author | pubmed-author:AngmanLL | lld:pubmed |
| pubmed-article:9127147 | pubmed:author | pubmed-author:GranzieroLL | lld:pubmed |
| pubmed-article:9127147 | pubmed:author | pubmed-author:LantelmeEE | lld:pubmed |
| pubmed-article:9127147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9127147 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:9127147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9127147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9127147 | pubmed:pagination | 49-56 | lld:pubmed |
| pubmed-article:9127147 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9127147 | pubmed:meshHeading | pubmed-meshheading:9127147-... | lld:pubmed |
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| pubmed-article:9127147 | pubmed:meshHeading | pubmed-meshheading:9127147-... | lld:pubmed |
| pubmed-article:9127147 | pubmed:meshHeading | pubmed-meshheading:9127147-... | lld:pubmed |
| pubmed-article:9127147 | pubmed:meshHeading | pubmed-meshheading:9127147-... | lld:pubmed |
| pubmed-article:9127147 | pubmed:meshHeading | pubmed-meshheading:9127147-... | lld:pubmed |
| pubmed-article:9127147 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9127147 | pubmed:articleTitle | Clonal predominance, but preservation of a polyclonal reservoir, in the normal alpha beta T-cell repertoire. | lld:pubmed |
| pubmed-article:9127147 | pubmed:affiliation | Department of Genetics, Biology, and Medical chemistry, University of Turin, Italy. | lld:pubmed |
| pubmed-article:9127147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9127147 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9127147 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9127147 | lld:pubmed |
