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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6627
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pubmed:dateCreated |
1997-5-22
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pubmed:abstractText |
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
pubmed-author:BronsonR TRT,
pubmed-author:DickinsonS LSL,
pubmed-author:FazeliAA,
pubmed-author:GordonJ IJI,
pubmed-author:HermistonM LML,
pubmed-author:Keino-MasuKK,
pubmed-author:NEFFB JBJ,
pubmed-author:RayburnHH,
pubmed-author:SimonsJJ,
pubmed-author:SmaleC JCJ,
pubmed-author:SteenR GRG,
pubmed-author:StoeckliE TET,
pubmed-author:Tessier-LavigneMM,
pubmed-author:TigheR VRV,
pubmed-author:WeinbergR ARA
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
386
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
796-804
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9126737-Animals,
pubmed-meshheading:9126737-Axons,
pubmed-meshheading:9126737-Brain,
pubmed-meshheading:9126737-Brain Neoplasms,
pubmed-meshheading:9126737-Cell Adhesion Molecules,
pubmed-meshheading:9126737-Cell Division,
pubmed-meshheading:9126737-Chimera,
pubmed-meshheading:9126737-Chromosome Mapping,
pubmed-meshheading:9126737-Colorectal Neoplasms,
pubmed-meshheading:9126737-Gene Targeting,
pubmed-meshheading:9126737-Genes, DCC,
pubmed-meshheading:9126737-Humans,
pubmed-meshheading:9126737-Intestinal Mucosa,
pubmed-meshheading:9126737-Intestinal Neoplasms,
pubmed-meshheading:9126737-Intestinal Polyps,
pubmed-meshheading:9126737-Mice,
pubmed-meshheading:9126737-Mice, Inbred C57BL,
pubmed-meshheading:9126737-Mutagenesis,
pubmed-meshheading:9126737-Nerve Growth Factors,
pubmed-meshheading:9126737-Phenotype,
pubmed-meshheading:9126737-Receptors, Cell Surface,
pubmed-meshheading:9126737-Spinal Cord,
pubmed-meshheading:9126737-Tumor Suppressor Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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