Linked Life Data

9126174

Source:http://linkedlifedata.com/resource/pubmed/id/9126174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-20
pubmed:abstractText
In this study we have investigated changes in glial cells of the cerebellum of cis-dichlorodiammine platinum (cisDDP)-treated rats. The expression of S-100 protein and glial fibrillary acidic protein (GFAP), taken as markers of glial cell function, was evaluated using immunocytochemical methods. In parallel, immunoreactivity for calbindin, parvalbumin, and phosphorylated 200-kDa neurofilament protein was observed in Purkinje cells as markers for neuronal integrity and activity. Results showed that, although no difference in the immunostaining of S-100 protein between control and treated animals could be observed, an increase in the frequency of GFAP immunoreactive cells was present in cisDDP-treated rats. In Purkinje cells, immunocytochemical expression of calbindin and parvalbumin was decreased after drug treatment. In addition, following immunoreaction for phosphorylated 200-kDa neurofilament protein, the somata of Purkinje cells, which were negative in control animals, were stained in treated rats. These findings suggest that cisDDP does not significantly interfere with pathways of glial cell activity and that the increased number of GFAP positive astrocytes may be due to an activation of glial cells consequent upon neuronal death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Glial cell reaction to cis-dichlorodiammine platinum treatment in the immature rat cerebellum.
pubmed:affiliation
Dipartimento di Biologia Animale, Università di Pavia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't