Linked Life Data

9125296

Source:http://linkedlifedata.com/resource/pubmed/id/9125296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-4-18
pubmed:abstractText
This study was designed to determine the effect of several hormone replacement therapies on LDL size, density, heterogeneity, and composition in surgically postmenopausal cynomolgus monkeys fed an atherogenic diet. Groups (n = 5 each) of ovariectomized cynomolgus monkeys were untreated (control), or treated with conjugated equine estrogens, medroxyprogesterone acetate (progesterone), combined estrogen-progesterone, or tamoxifen for 9 weeks. There were no differences among treatment groups in total plasma, LDL, or HDL cholesterol or triglyceride concentrations. Plasma LDL were isolated by ultracentrifugation and size exclusion chromatography and subfractionated by density gradient centrifugation for subsequent chemical analysis. Estrogen treatment was associated with significantly smaller (measured as LDL molecular weight, 3.9 +/- 0.2 g/mu mol) and denser plasma LDL (1.034 g/ml peak density) compared with control (4.5 +/- 0.1 g/mu mol; 1.030 g/ml peak density) or progesterone-treated animals (4.6 +/- 0.2; 1.029 g/ml peak density). LDL from the estrogen group were relatively enriched in protein and triglyceride and poor in cholesteryl ester and apolipoprotein F (apoE) compared to the control group. Triglyceride enrichment with estrogen treatment occurred predominantly in the lighter, larger LDL subfractions (d = 1.015-1.025 g/ml), which were reduced in concentration (26 +/- 10 mg cholesterol/dl) compared to control (61 +/- 19 mg/dl) or progesterone treated animals (67 +/- 16 mg/dl). Combined estrogen-progesterone or tamoxifen treatment resulted in changes in LDL that followed the same trend as those observed with estrogen treatment. We conclude that short-term estrogen treatment of ovariectomized cynomolgus monkeys results in changes in plasma LDL size, density, and composition while having no apparent effect on overall plasma lipid concentrations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-29
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9125296-Administration, Oral, pubmed-meshheading:9125296-Animals, pubmed-meshheading:9125296-Apolipoproteins B, pubmed-meshheading:9125296-Apolipoproteins E, pubmed-meshheading:9125296-Cholesterol, LDL, pubmed-meshheading:9125296-Coronary Artery Disease, pubmed-meshheading:9125296-Disease Models, Animal, pubmed-meshheading:9125296-Drug Therapy, Combination, pubmed-meshheading:9125296-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:9125296-Estrogen Antagonists, pubmed-meshheading:9125296-Estrogen Replacement Therapy, pubmed-meshheading:9125296-Estrogens, Conjugated (USP), pubmed-meshheading:9125296-Female, pubmed-meshheading:9125296-Lipoproteins, LDL, pubmed-meshheading:9125296-Macaca fascicularis, pubmed-meshheading:9125296-Ovariectomy, pubmed-meshheading:9125296-Postmenopause, pubmed-meshheading:9125296-Progesterone, pubmed-meshheading:9125296-Tamoxifen
pubmed:year
1996
pubmed:articleTitle
Effects of hormone replacement modalities on low density lipoprotein composition and distribution in ovariectomized cynomolgus monkeys.
pubmed:affiliation
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't