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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-4-24
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pubmed:abstractText |
Congenital heart block (CHB), associated with antibodies to SS-A/Ro and SS-B/La, is most often detected between 18 and 24 weeks of gestation, yet the maternal heart is unaffected. We recently described an alternatively spliced 52-kd SS-A/Ro messenger RNA (mRNA) derived from the skipping of exon 4 which encodes a smaller protein, 52beta (MW 45 kd), recognized by CHB maternal antisera. This study was designed to identify whether cardiac expression of 52beta and full-length 52alpha relates to the development of CHB.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
655-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9125247-Adult,
pubmed-meshheading:9125247-Alternative Splicing,
pubmed-meshheading:9125247-Autoantigens,
pubmed-meshheading:9125247-DNA Primers,
pubmed-meshheading:9125247-Embryonic and Fetal Development,
pubmed-meshheading:9125247-Female,
pubmed-meshheading:9125247-Fetal Heart,
pubmed-meshheading:9125247-Gestational Age,
pubmed-meshheading:9125247-Heart Block,
pubmed-meshheading:9125247-Humans,
pubmed-meshheading:9125247-Molecular Weight,
pubmed-meshheading:9125247-Myocardium,
pubmed-meshheading:9125247-Polymerase Chain Reaction,
pubmed-meshheading:9125247-Pregnancy,
pubmed-meshheading:9125247-RNA, Messenger,
pubmed-meshheading:9125247-RNA, Small Cytoplasmic,
pubmed-meshheading:9125247-Ribonucleoproteins
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pubmed:year |
1997
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pubmed:articleTitle |
Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development.
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pubmed:affiliation |
New York University School of Medicine and Hospital for Joint Diseases, New York, NY 10003, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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