Linked Life Data

9124839

Source:http://linkedlifedata.com/resource/pubmed/id/9124839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-4-24
pubmed:abstractText
A randomized, multicenter, investigator-blind trial was conducted to compare the efficacies of cefuroxime axetil and ciprofloxacin for treatment of patients with uncomplicated gonorrhea caused by penicillinase-producing Neisseria gonorrhoeae (PPNG). A total of 832 patients (434 females and 398 males) received a single oral dose of cefuroxime axetil (1,000 mg [417 patients]) or ciprofloxacin (500 mg [415 patients]). N. gonorrhoeae was eradicated from the cervix in 114 of 118 (97%) and 118 of 119 (99%) bacteriologically evaluable females treated with cefuroxime axetil and ciprofloxacin, respectively (P = 0.213; difference, -2%; 95% confidence interval, -6 to 1%), and from the urethra in 154 of 166 (93%) and 171 of 171 (100%) bacteriologically evaluable male patients treated with cefuroxime axetil and ciprofloxacin, respectively (P < 0.001; difference, -7%; 95% confidence interval, -11 to -3%). Both treatments were effective in eradicating N. gonorrhoeae in females with rectal infections (cefuroxime axetil, 29 of 30 [97%]; ciprofloxacin, 25 of 25 [100%]; P = 1.00). In small numbers of patients, cefuroxime axetil was less effective than ciprofloxacin in treating males with pharyngeal infections (eradication in 4 of 10 and in 8 of 8 patients, respectively; P = 0.013). PPNG was eradicated from the cervix in 22 of 23 (96%) and 32 of 32 (100%) bacteriologically evaluable female patients treated with cefuroxime axetil and ciprofloxacin, respectively (P = 0.418; difference, -4%; 95% confidence interval, -13 to 4%), and from the urethra in 35 of 36 (97%) and 34 of 34 (100%) bacteriologically evaluable male patients treated with cefuroxime axetil and ciprofloxacin, respectively (P = 1.00; difference, -3%; 95% confidence interval, -8 to 3%). The incidences of drug-related adverse events were similar for the two study drugs. In summary, treatment with a single oral dose of cefuroxime axetil is as effective as treatment with a single oral dose of ciprofloxacin in eradicating PPNG from males and females with uncomplicated gonorrhea (urethral and endocervical), and both regimens are well-tolerated. However, in the present study, cefuroxime axetil was less effective than ciprofloxacin in treating urethral gonococcal infections in male patients, although both study drugs were highly effective in treating cervical gonococcal infections in female patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-1922235, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-1939563, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-20919386, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-2117303, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-2764526, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-3733084, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-3767347, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-3936198, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-6344037, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-6349019, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-7811045, http://linkedlifedata.com/resource/pubmed/commentcorrection/9124839-7811047
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2775-80
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Comparison of single-dose cefuroxime axetil with ciprofloxacin in treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing Neisseria gonorrhoeae strains.
pubmed:affiliation
Shelby County Health Department STD Clinic, Memphis, Tennessee, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study