Linked Life Data

9124345

Source:http://linkedlifedata.com/resource/pubmed/id/9124345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1997-4-24
pubmed:abstractText
The mechanism of associated fluctuations in plasma motilin and pancreatic polypeptide (PP) concentrations was studied in fasted conscious dogs while gastric motility was monitored. Plasma motilin and PP concentrations were measured by radioimmunoassay. In intact normal dogs, exogenous motilin (0.03-0.3 g/kg) stimulated dose-related release of PP, but PP did not stimulate motilin release. Motilin-induced PP release was completely inhibited by pretreatment with cholinergic blockers and a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, and by vagotomy. The cyclic release of PP was abolished after vagotomy and duodenectomy. However, PP release stimulated by exogenous motilin was apparent after duodenectomy but not after vagotomy. In conclusion, motilin appears to stimulate PP release via vagal, cholinergic muscarinic pathways involving 5-HT3 receptors and to act as a biosignal controlling PP release by mediating the interdigestive periodic changes in the duodenum to the center of the autonomic nervous system. This represents a new role for motilin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G224-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Motilin is a biosignal controlling cyclic release of pancreatic polypeptide via the vagus in fasted dogs.
pubmed:affiliation
Gastrointestinal Research Laboratories, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't