Linked Life Data

9124297

Source:http://linkedlifedata.com/resource/pubmed/id/9124297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1997-4-24
pubmed:abstractText
Ureteral myocytes of guinea pigs have L-type Ca2+ channels (I(Ca)). In 3 mM Ca2+, maximum I(Ca) was 3.38 microA/cm2. Voltage at which conductance is 50% of maximum (V0.5) of I(Ca) was -1.0 mV in 3 mM Ca2+ and +22 mV in 30 mM Ca2+, with slope factors of 8 mV. V0.5 of steady-state inactivation of I(Ca) was -16.2 and +1.1 mV in 3 and 30 mM Ca2+, respectively, with similar slope factors of about -6 mV. A window current reaching 20-25% of the maximum I(Ca) was active between -20 and 0 mV. I(Ca) inactivated very slowly, with time constants of 217.6 and 2,455.9 ms with no voltage dependency. When Ba2+ was used as the charge carrier, the amplitude and inactivation kinetics of the Ba2+ current were similar to those for I(Ca). These results indicate that the ureteral myocyte has little Ca2+-mediated Ca2+ channel inactivation, a feature significantly associated with the slow I(Ca) inactivation. The slow inactivation and the window current are essential for the sustained membrane depolarization during the plateau of ureteral action potentials.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
C543-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Properties of inward calcium current in guinea pig ureteral myocytes.
pubmed:affiliation
Department of Pharmacology, State University of New York Health Science Center at Brooklyn, 11203, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.