Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-4-21
pubmed:abstractText
We investigated the relationship between changes in hemostatic factors and postangioplasty restenosis by evaluating plasma levels of P-selectin, beta-thromboglobulin (BTG), and other markers of the coagulation-fibrinolysis system. Seventy-three consecutive patients (56 men and 17 women) undergoing elective percutaneous transluminal coronary angioplasty (PTCA) were enrolled in this study. Patients with acute myocardial infarction within the previous month, unstable angina pectoris, chronic total occlusion, target lesions involving saphenous vein grafts, or coronary artery bypass grafting within the previous 6 months were excluded. Fasting blood samples were obtained before elective PTCA and at follow-up coronary angiography. In patients with restenosis, plasminogen activator inhibitor type-1 (PAI-1) levels were significantly higher (88.2 +/- 36.1 vs 118.5 +/- 50.0 ng/dl; p< 0.05) and plasmin-plasmin inhibitor complex (PIC) levels were significantly lower (0.76 +/- 0.26 vs 0.61 +/- 0.26 microg/ml; p < 0.02) than at baseline. P-Selectin levels were also significantly higher (192 +/- 68 vs 239 +/- 99 ng/ dl; p<0.01) and a positive correlation existed between P-selectin and BTG levels (r= 0.43; p< 0.05). The higher PAI-1 and lower PIC levels in patients with postangioplasty restenosis suggest that impaired fibrinolysis may play a role in the pathogenesis of restenosis, whereas the positive correlation between P-selectin and BTG levels implies a role for activated platelets in restenosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antifibrinolytic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antithrombin III, http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolysin, http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1, http://linkedlifedata.com/resource/pubmed/chemical/Tissue Plasminogen Activator, http://linkedlifedata.com/resource/pubmed/chemical/alpha-2-Antiplasmin, http://linkedlifedata.com/resource/pubmed/chemical/antithrombin III-protease complex, http://linkedlifedata.com/resource/pubmed/chemical/beta-Thromboglobulin, http://linkedlifedata.com/resource/pubmed/chemical/plasmin-plasmin inhibitor complex
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-92
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:9124158-Angioplasty, Balloon, Coronary, pubmed-meshheading:9124158-Antifibrinolytic Agents, pubmed-meshheading:9124158-Antithrombin III, pubmed-meshheading:9124158-Blood Coagulation, pubmed-meshheading:9124158-Case-Control Studies, pubmed-meshheading:9124158-Coronary Disease, pubmed-meshheading:9124158-Female, pubmed-meshheading:9124158-Fibrinolysin, pubmed-meshheading:9124158-Fibrinolysis, pubmed-meshheading:9124158-Follow-Up Studies, pubmed-meshheading:9124158-Humans, pubmed-meshheading:9124158-Male, pubmed-meshheading:9124158-Middle Aged, pubmed-meshheading:9124158-P-Selectin, pubmed-meshheading:9124158-Peptide Hydrolases, pubmed-meshheading:9124158-Plasminogen Activator Inhibitor 1, pubmed-meshheading:9124158-Platelet Activation, pubmed-meshheading:9124158-Recurrence, pubmed-meshheading:9124158-Tissue Plasminogen Activator, pubmed-meshheading:9124158-alpha-2-Antiplasmin, pubmed-meshheading:9124158-beta-Thromboglobulin
pubmed:year
1997
pubmed:articleTitle
Postangioplasty restenosis: platelet activation and the coagulation-fibrinolysis system as possible factors in the pathogenesis of restenosis.
pubmed:affiliation
Cardiovascular Center, Toranomon Hospital, Tokyo, Japan.
pubmed:publicationType
Journal Article, Comparative Study