Linked Life Data

9122534

Source:http://linkedlifedata.com/resource/pubmed/id/9122534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-4-18
pubmed:abstractText
In order to better elucidate the immunological effect of opioid abuse in the absence of HIV infection as a confounding factor, granulocyte function was investigated in 3 groups of HIV negative subjects including 20 active parenteral heroin abusers (E), 20 long-treatment methadone-maintained former opiate abusers (M) and 20 healthy controls. Chemotaxis to fMLP, casein and activated plasma were markedly and similarly reduced (approximately 50%) in both E and M groups, as true for superoxide production after fMLP and PMA stimulation, 47% decrease of C values. PMNs of E and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment with values that were lower than 10% of those in controls as observed by flow cytometry. In parallel, PMNs of E and M individuals presented an approximately four fold increase in opioid receptors number compared to controls, a significant inverse correlation existing between the increase in opiate receptors and defective chemotaxis. The possible mechanism retaining the observed changes in PMNs of E and M individuals are discussed.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-1193
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
530-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Opioid receptors and phagocyte defects in drug addicts].
pubmed:affiliation
Dipartimento di Medicina Interna e Terapia Medica, Università, IRCCS Policlinico San Matteo, Pavia.
pubmed:publicationType
Journal Article, English Abstract