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rdf:type |
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lifeskim:mentions |
umls-concept:C0033164,
umls-concept:C0036457,
umls-concept:C0178539,
umls-concept:C0439836,
umls-concept:C0439851,
umls-concept:C0597298,
umls-concept:C0599896,
umls-concept:C1519249,
umls-concept:C1552596,
umls-concept:C1947931,
umls-concept:C2587213
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pubmed:issue |
6
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pubmed:dateCreated |
1997-4-24
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pubmed:abstractText |
Efficient formation of scrapie isoform of prion protein (PrP(Sc)) requires targeting PrP(Sc) by glycophosphatidyl inositol (GPI) anchors to caveolae-like domains (CLDs). Redirecting the cellular isoform of prion protein (PrP(C)) to clathrin-coated pits by creating chimeric PrP molecules with four different COOH-terminal transmembrane domains prevented the formation of PrP(Sc). To determine if these COOH-terminal transmembrane segments prevented PrP(C) from refolding into PrP(Sc) by altering the structure of the polypeptide, we fused the 28-aa COOH termini from the Qa protein. Two COOH-terminal Qa segments differing by a single residue direct the transmembrane protein to clathrin-coated pits or the GPI form to CLDs; PrP(Sc) was formed from GPI-anchored PrP(C) but not from transmembrane PrP(C). Our findings argue that PrP(Sc) formation is restricted to a specific subcellular compartment and as such, it is likely to involve auxiliary macromolecules found within CLDs.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1338978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1348570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1352803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1353761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1356522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1363897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1364076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1531449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1532143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1680859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1682507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1684401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1693623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1719082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1825341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1967489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-1974464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-2444340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-2446004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-2505674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-2562814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-3052274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-3282080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-3693391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-6205119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-6686005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-6818988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7479734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7537273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7553876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7609638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7698979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7731991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7826022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7902565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7902575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7911471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7933137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-7983747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8024796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8100741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8349730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8425894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8448158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8454641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8475059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8676499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8700211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9122195-8962161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2333-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
