|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1997-4-24
|
|
pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X97650,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X98411,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X98507,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X99638,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78141,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78142,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78143,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78144,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78145,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78146,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78147,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78148,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78149,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78150,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78151,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78152,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78153,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78154,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78155,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78156,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78157,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78158,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78159,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78160,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78161,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78162,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z78163
|
|
pubmed:abstractText |
Several lines of evidence indicate a crucial role for unconventional myosins in the function of the sensory hair cells of the inner ear. We report here the characterization of the cDNAs encoding two unconventional type I myosins from a mouse cochlear cDNA library. The first cDNA encodes a putative protein named Myo1c, which is likely to be the murine orthologue of the bullfrog myosin I beta and which may be involved in the gating of the mechanotransduction channel of the sensory hair cells. This myosin belongs to the group of short-tailed myosins I, with its tail ending shortly after a polybasic, TH-1-like domain. The second cDNA encodes a novel type I myosin Myo1f which displays three regions: a head domain with the conserved ATP- and actin-binding sites, a neck domain with a single IQ motif, and a tail domain with the tripartite structure initially described in protozoan myosins I. The tail of Myo1f includes (1) a TH-1 region rich in basic residues, which may interact with anionic membrane phospholipids; (2) a TH-2 proline-rich region, expected to contain an ATP-insensitive actin-binding site; and (3) a SH-3 domain found in a variety of cytoskeletal and signaling proteins. Northern blot analysis indicated that the genes encoding Myo1c and Myo1f display a widespread tissue expression in the adult mouse. Myo1c and Myo1f were mapped by in situ hybridization to the chromosomal regions 11D-11E and 17B-17C, respectively. The human orthologuous genes MYO1C and MYO1F were also characterized, and mapped to the human chromosomal regions 17p18 and 19p13.2-19p13.3, respectively.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0888-7543
|
|
pubmed:author |
pubmed-author:BlanchardSS,
pubmed-author:CrozetFF,
pubmed-author:DepétrisDD,
pubmed-author:FizamesCC,
pubmed-author:HamelCC,
pubmed-author:LenoirMM,
pubmed-author:Levi-AcobasFF,
pubmed-author:MatteiM GMG,
pubmed-author:PetitCC,
pubmed-author:PujolRR,
pubmed-author:RipollCC,
pubmed-author:VagoPP,
pubmed-author:WeirBB,
pubmed-author:el AmraouiAA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
40
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
332-41
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9119401-Amino Acid Sequence,
pubmed-meshheading:9119401-Animals,
pubmed-meshheading:9119401-Base Sequence,
pubmed-meshheading:9119401-Chromosome Mapping,
pubmed-meshheading:9119401-Cloning, Molecular,
pubmed-meshheading:9119401-Cochlea,
pubmed-meshheading:9119401-DNA, Complementary,
pubmed-meshheading:9119401-Gene Expression Regulation,
pubmed-meshheading:9119401-Gene Library,
pubmed-meshheading:9119401-Genes,
pubmed-meshheading:9119401-Humans,
pubmed-meshheading:9119401-Kidney,
pubmed-meshheading:9119401-Mice,
pubmed-meshheading:9119401-Mice, Inbred BALB C,
pubmed-meshheading:9119401-Molecular Sequence Data,
pubmed-meshheading:9119401-Myosins,
pubmed-meshheading:9119401-Organ Specificity,
pubmed-meshheading:9119401-RNA, Messenger,
pubmed-meshheading:9119401-Sequence Homology, Amino Acid,
pubmed-meshheading:9119401-Sequence Homology, Nucleic Acid
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.
|
|
pubmed:affiliation |
Unité de Génétique Moléculaire Humaine, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
