Linked Life Data

9116328

Source:http://linkedlifedata.com/resource/pubmed/id/9116328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-4-24
pubmed:abstractText
We examined the effects of sucralfate and its components on indomethacin-induced damage to cultured rabbit gastric mucosal cells. Cell viability was assessed by colorimetric and dye exclusion methods. Exposure of mucosal cells to indomethacin at 50 and 500 microM for 4 hr significantly reduced their viability, the viability loss being bout 40% and about 90% respectively. Pretreatment of the cells with sucralfate for 30 min prevented the reduction in viability caused by 50 microM indomethacin in a dose-related manner. Furthermore, sucralfate also significantly protected mucosal cells against severe damage caused by 500 microM indomethacin. However, neither sucrose octasulfate nor Al(OH)3. (the components of sucralfate) significantly prevented the reduction in viability caused by 50 and 500 microM indomethacin, although these components tended to inhibit the viability loss. When mucosal cells were incubated with sucralfate or its components for 4 hr, the drugs did not affect the cell viability. These results indicate that sucralfate directly protects gastric mucosal cells against cell damage caused by indomethacin, and that the protective effect of sucralfate might be expressed as a synergistic action of its components.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0867-5910
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effects of sucralfate and its components on indomethacin-induced damage to cultured rabbit gastric mucosal cells.
pubmed:affiliation
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
pubmed:publicationType
Journal Article, Comparative Study