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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1977-12-29
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pubmed:abstractText |
1 We have measured the plasma concentration of acebutolol and a major metabolite in patients on chronic oral therapy with this drug, using a new assay, specific for each species. Our study suggests: 2 The acetyl metabolite was present in concentrations greater than those of acebutolol at all times during the dosing interval in all seven subjects. 3 The ratio of the mean steady-state plasma concentrations of the acetyl metabolite to unchanged acebutolol was 2.7 +/- 1.0. 4 Previous studies using non-specific methods that measure plasma concentrations of the acetyl metabolite and acebutolol as a single species cannot be used to determine pharmacokinetic parameters or to provide reliable correlations of plasma drug concentration with effect. 5 Future studies determining plasma concentration of acebutolol should take this metabolite into account. 6 Further work will be necessary to determine the metabolite's contribution to acebutolol's effects in man.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-1122675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-1233201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-1269192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-2088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4146876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4147192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4150954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4823626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4892569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4912962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-49736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-4998689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-55060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-66105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-6757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-766682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-768905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-788740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-968178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-973938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/911602-9955
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1977
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pubmed:articleTitle |
Acebutolol metabolite plasma concentration during chronic oral therapy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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