Linked Life Data

9115978

Source:http://linkedlifedata.com/resource/pubmed/id/9115978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-4-21
pubmed:abstractText
Slipped DNA structures can occur in sequences with direct repeats. DNA triplet repeats, particularly (CTG)n, (CGC)n, and (GAA)n, are known to be associated with several neurological diseases. Slippage is probably the cause of expansion of the number of repeats, a process called dynamic mutation, which is known to be the cause of the diseased state. Here it is shown that the conformational entropy associated with slippage is more destabilizing for long direct repeats (300-1000 base pairs) than shorter runs (10-30 base pairs), by about 2 kcal/mol. This contributes to the greater instability of longer sequences. Entropic considerations also favor the formation of simple bulges, rather than hairpin structures. A model is presented for dynamic mutations, and experimentally testable predictions are made that will allow the model to be tested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3047-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Slipped structures in DNA triplet repeat sequences: entropic contributions to genetic instabilities.
pubmed:affiliation
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294, USA. harvey@neptune.cmc.uab.edu
pubmed:publicationType
Journal Article