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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-5-2
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pubmed:abstractText |
Mice (Pdegtm1/Pdegtm1) homozygous for a mutant allele of the gamma subunit of retinal cyclic guanosine monophosphate phosphodiesterase (PDE gamma) suffer a severe photoreceptor degeneration. To determine whether the antiapoptotic BCL2 gene is effective in delaying the cell death pathway in this new strain of mutant mice, a transgene encoding the BCL2 gene product was introduced by mating into the mutant background, and the resulting mice were examined for possible rescue of the retinal degeneration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
943-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9112990-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:9112990-Animals,
pubmed-meshheading:9112990-Apoptosis,
pubmed-meshheading:9112990-Cell Survival,
pubmed-meshheading:9112990-Electrophoresis, Agar Gel,
pubmed-meshheading:9112990-Electroretinography,
pubmed-meshheading:9112990-Female,
pubmed-meshheading:9112990-Gene Expression,
pubmed-meshheading:9112990-Genes, Suppressor,
pubmed-meshheading:9112990-Genes, bcl-2,
pubmed-meshheading:9112990-Genotype,
pubmed-meshheading:9112990-Male,
pubmed-meshheading:9112990-Mice,
pubmed-meshheading:9112990-Mice, Mutant Strains,
pubmed-meshheading:9112990-Mice, Transgenic,
pubmed-meshheading:9112990-Photoreceptor Cells,
pubmed-meshheading:9112990-Polymerase Chain Reaction,
pubmed-meshheading:9112990-Retinal Degeneration
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pubmed:year |
1997
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pubmed:articleTitle |
Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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