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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-6-23
|
| pubmed:abstractText |
1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0306-3623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
119-21
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9112087-Animals,
pubmed-meshheading:9112087-Brain Chemistry,
pubmed-meshheading:9112087-Head Injuries, Closed,
pubmed-meshheading:9112087-Hydrogen-Ion Concentration,
pubmed-meshheading:9112087-Magnesium,
pubmed-meshheading:9112087-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9112087-Male,
pubmed-meshheading:9112087-Rats,
pubmed-meshheading:9112087-Rats, Wistar
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.
|
| pubmed:affiliation |
Department of Pharmacology, Saitama Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|