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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-5-8
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pubmed:abstractText |
Syphilis remains a major cause of premature birth, fetal and perinatal death, and congenital syphilis in South Africa, despite systematic antenatal screening by rapid plasma reagin and treatment with 2.4 million U of benzathine penicillin G.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Antibiotics--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/DRUGS,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy Outcomes,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnant Women,
http://linkedlifedata.com/resource/pubmed/keyword/Prospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Tract Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/SOUTH AFRICA,
http://linkedlifedata.com/resource/pubmed/keyword/Sexually Transmitted Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Southern Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Syphilis--prevention and control,
http://linkedlifedata.com/resource/pubmed/keyword/Treatment
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0148-5717
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-101
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pubmed:dateRevised |
2009-11-19
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pubmed:otherAbstract |
PIP: To determine whether the US Centers for Disease Control guideline of 1 injection of 2.4 million U of benzathine penicillin G is sufficient treatment for early syphilis in pregnant women, this regimen was tested in 180 human immunodeficiency virus-negative urban Black women with syphilis presenting to Kalafong Hospital in Pretoria, South Africa, during 1988-90. A favorable pregnancy outcome was recorded in 108 women who received 2 or 3 weekly intragluteal injections. On the other hand, 1 injection was associated with lower birth weight, increased prematurity and total preterm birth rate, and increased total pregnancy loss and neonatal mortality. These outcomes were reanalyzed after exclusion of women treated with oral penicillin derivatives and adjusted for the estimated duration of treponemicidal levels at 3 weeks post-injection. Birth weight was significantly lower for treponemicidal coverage of 3 weeks or less compared to coverage lasting more than 3 weeks (2748 and 3130 grams, respectively). Also increased when coverage was less than 3 weeks were the relative risks for prematurity (8.5), perinatal mortality (20.5), and congenital syphilis (2.0). Impaired outcome associated with short treatment was clustered in women who attended prenatal care before the 28th week of gestation and those whose initial rapid plasma reagin titer exceeded 16. These findings indicate that the standard protocol is not adequate in areas where syphilis is endemic. Recommended is administration of 2 injections of 2.4 million U benzathine penicillin at least 1 week apart, preferably 4 weeks or more before delivery.
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pubmed:meshHeading |
pubmed-meshheading:9111755-Adult,
pubmed-meshheading:9111755-Birth Weight,
pubmed-meshheading:9111755-Female,
pubmed-meshheading:9111755-HIV Seronegativity,
pubmed-meshheading:9111755-Humans,
pubmed-meshheading:9111755-Infant, Newborn,
pubmed-meshheading:9111755-Injections, Intramuscular,
pubmed-meshheading:9111755-Penicillin G Benzathine,
pubmed-meshheading:9111755-Penicillins,
pubmed-meshheading:9111755-Pregnancy,
pubmed-meshheading:9111755-Pregnancy Complications, Infectious,
pubmed-meshheading:9111755-Syphilis,
pubmed-meshheading:9111755-Treatment Failure
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pubmed:year |
1997
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pubmed:articleTitle |
Apparent failure of one injection of benzathine penicillin G for syphilis during pregnancy in human immunodeficiency virus-seronegative African women.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Belgium.
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pubmed:publicationType |
Journal Article
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