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rdf:type |
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lifeskim:mentions |
umls-concept:C0009368,
umls-concept:C0027028,
umls-concept:C0205088,
umls-concept:C0242402,
umls-concept:C0332206,
umls-concept:C0598964,
umls-concept:C0599756,
umls-concept:C0999699,
umls-concept:C1280500,
umls-concept:C1709059,
umls-concept:C2003941
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pubmed:issue |
2
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pubmed:dateCreated |
1997-5-12
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pubmed:abstractText |
We have studied the effect of [D-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin (DAMGO, opioid mu-receptor agonist) and ICI-204,448 (kappa-receptor agonist) on endogenous noradrenaline release in the guinea-pig isolated distal colon. DAMGO enhances noradrenaline over-flow and this effect is antagonized by naloxone (pIC50 = 10.27) and nor-binaltorphimine (pIC50 = 7.97), and concentration-dependently turned into inhibition by yohimbine. ICI-204,448 inhibits noradrenaline overflow and is antagonized by naloxone (pIC50 = 9.38) and nor-binaltorphimine (pIC50 = 10.48), but is not affected by yohimbine. Evidence is thus given that mu- and kappa-opioid receptors modulate noradrenaline release in the guinea-pig colon. Modifications by yohimbine of the effect of DAMGO indicate the existence of a functional relationship between mu-receptors and alpha(2)-autoreceptors in this model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/ICI 204448,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine,
http://linkedlifedata.com/resource/pubmed/chemical/norbinaltorphimine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
222
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9111732-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:9111732-Adrenergic alpha-Agonists,
pubmed-meshheading:9111732-Adrenergic alpha-Antagonists,
pubmed-meshheading:9111732-Analgesics,
pubmed-meshheading:9111732-Animals,
pubmed-meshheading:9111732-Colon,
pubmed-meshheading:9111732-Dose-Response Relationship, Drug,
pubmed-meshheading:9111732-Electric Stimulation,
pubmed-meshheading:9111732-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:9111732-Enkephalins,
pubmed-meshheading:9111732-Guinea Pigs,
pubmed-meshheading:9111732-Myenteric Plexus,
pubmed-meshheading:9111732-Naloxone,
pubmed-meshheading:9111732-Naltrexone,
pubmed-meshheading:9111732-Narcotic Antagonists,
pubmed-meshheading:9111732-Neurotransmitter Agents,
pubmed-meshheading:9111732-Norepinephrine,
pubmed-meshheading:9111732-Pyrrolidines,
pubmed-meshheading:9111732-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:9111732-Receptors, Opioid, kappa,
pubmed-meshheading:9111732-Receptors, Opioid, mu,
pubmed-meshheading:9111732-Yohimbine
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pubmed:year |
1997
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pubmed:articleTitle |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, II Faculty of Medicine, University of Pavia, Varese VA, Italy.
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pubmed:publicationType |
Journal Article
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