Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-6-27
|
| pubmed:abstractText |
Eight pony mares received 4 mg of recombinant porcine prolactin (rpPRL) daily for 45 d beginning on January 15; eight control mares received vehicle. Reproductive end points and various indicators of metabolism, hair shedding, and thyroid activity were monitored. Prolactin concentrations peaked in mares treated with rpPRL at 94 +/- 19 ng/mL 2 h after injection and were 5.1 +/- 1.7 ng/mL 24 h after injection. Treatment with rpPRL increased (P < .01) hair shedding within 14 d, which peaked at 28 d and then dropped precipitously. Binding of 125I-equine prolactin confirmed that antibodies were present in rpPRL-treated mares by 28 d, thus only data up to that time are included herein. The percentage of mares in estrus after 17 d of treatment was greater (P < .05) for mares treated with rpPRL than for controls, although the average day of estrus onset did not differ (P > .1). The date of first ovulation, determined from plasma progesterone concentrations, was hastened (P < .005) in mares treated with rpPRL (February 6 +/- 3 d) relative to control mares (March 14 +/- 6 d). Concentrations of insulin-like growth factor I and nonesterified fatty acids were not affected (P < .05) over time. There were minor differences between groups in thyroid hormone secretion. Various assessments of glucose and insulin indicated no perturbation (P > .1) due to treatment with rpPRL. We conclude that prolactin mediates the onset of vernal hair shedding in mares and is in some way involved with ovulation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-8812
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
75
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1092-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9110225-Anestrus,
pubmed-meshheading:9110225-Animals,
pubmed-meshheading:9110225-Antibodies,
pubmed-meshheading:9110225-Blood Glucose,
pubmed-meshheading:9110225-Estrus,
pubmed-meshheading:9110225-Fatty Acids, Nonesterified,
pubmed-meshheading:9110225-Female,
pubmed-meshheading:9110225-Fertility,
pubmed-meshheading:9110225-Follicle Stimulating Hormone,
pubmed-meshheading:9110225-Gonadotropins,
pubmed-meshheading:9110225-Hair,
pubmed-meshheading:9110225-Horses,
pubmed-meshheading:9110225-Hydrocortisone,
pubmed-meshheading:9110225-Insulin-Like Growth Factor I,
pubmed-meshheading:9110225-Iodine Radioisotopes,
pubmed-meshheading:9110225-Luteinizing Hormone,
pubmed-meshheading:9110225-Ovarian Follicle,
pubmed-meshheading:9110225-Ovary,
pubmed-meshheading:9110225-Ovulation,
pubmed-meshheading:9110225-Prolactin,
pubmed-meshheading:9110225-Reproduction,
pubmed-meshheading:9110225-Seasons
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Prolactin administration to seasonally anestrous mares: reproductive, metabolic, and hair-shedding responses.
|
| pubmed:affiliation |
Department of Animal Science, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge 70803-4210, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|