Linked Life Data

9109658

Source:http://linkedlifedata.com/resource/pubmed/id/9109658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1997-5-12
pubmed:abstractText
Resonance Raman measurements carried out in parallel on ferrous and ferric Scapharca inaequivalvis dimeric hemoglobin cyanide derivatives allowed the identification of the electron density marker bands and heme core size marker bands in both derivatives in comparison with those obtained for the carbonmonoxy and deoxy adducts. The iron cyanide stretching mode, measured for the first time in a ferrous hemoprotein, has been detected at 455 cm(-1), only 6 cm(-1) lower than in the corresponding ferric derivative. This finding demonstrates that the large free energy difference for complex formation between the two derivatives is not concentrated on the Fe-C bond. The internal stretching frequencies of the ligand in the ferric and ferrous derivatives have been identified by FTIR and Raman measurements using different cyanide isotopes. The frequency decreases in the order Fe(III)-CN adduct, free cyanide, Fe(II)-CN adduct, consistent with the behavior observed in inorganic complexes and horseradish peroxidase. The main feature emerging from these data is that cyanide, at variance with oxygen and carbon monoxide, binds to ferrous iron with only a minor perturbation of the electronic structure of the heme. The functional counterpart of this effect is the absence of cooperative cyanide binding in HbI.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4505-9
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Stereochemistry of the Fe(II)- and Fe(III)-cyanide complexes of the homodimeric Scapharca inaequivalvis hemoglobin. A resonance Raman and FTIR study.
pubmed:affiliation
Department of Biochemical Sciences, University La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article