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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1997-5-15
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pubmed:abstractText |
The ergot alkaloid bromocriptine (BKT) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (NOS) (IC50 = 10 +/- 2 microM) whereas it was poorly active towards inducible macrophage NOS (IC50 > 100 microM). BKT affects the activation of NOS by calmodulin, as it not only inhibits L-arginine oxidation to NO and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by neuronal NOS. These results suggest that BKT could exert some of its therapeutic effects by interfering with the NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
406
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9109381-Animals,
pubmed-meshheading:9109381-Brain,
pubmed-meshheading:9109381-Bromocriptine,
pubmed-meshheading:9109381-Catalysis,
pubmed-meshheading:9109381-Enzyme Inhibitors,
pubmed-meshheading:9109381-Mice,
pubmed-meshheading:9109381-Mice, Inbred C3H,
pubmed-meshheading:9109381-NADP,
pubmed-meshheading:9109381-Nitric Oxide Synthase,
pubmed-meshheading:9109381-Oxidation-Reduction,
pubmed-meshheading:9109381-Rats,
pubmed-meshheading:9109381-Recombinant Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.
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pubmed:affiliation |
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Paris, France.
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pubmed:publicationType |
Journal Article
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