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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-6-27
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pubmed:abstractText |
The effects of N-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, were examined on Mg2+-free-induced epileptiform activity, in guinea-pig piriform cortex slices in vitro. L-NAME (0.1-1 mM) had no effect on neuronal membrane properties or electrically-evoked postsynaptic potentials (PSPs). In contrast, during superfusion of the slices with Mg2+-free solution neurones exhibited spontaneous and stimulus-evoked epileptiform potentials that were suppressed in the presence of L-NAME (100 microM) or the selective NMDA receptor antagonist DL-APV (100 microM). The inhibitory effects induced by L-NAME were reversibly reduced by L-arginine (1 mM), but not D-arginine (1 mM), the latter drug not being a substrate for NO formation. It was concluded that L-NAME can suppress epileptiform activity induced by Mg2+-free exposure primarily through a decrease in presynaptic transmitter release, although additional actions on the NMDA-receptor complex were also considered.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-1298
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
452-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9109360-Animals,
pubmed-meshheading:9109360-Cerebral Cortex,
pubmed-meshheading:9109360-Epilepsy,
pubmed-meshheading:9109360-Female,
pubmed-meshheading:9109360-Guinea Pigs,
pubmed-meshheading:9109360-Magnesium,
pubmed-meshheading:9109360-Male,
pubmed-meshheading:9109360-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9109360-Neurons,
pubmed-meshheading:9109360-Nitric Oxide Synthase
|
pubmed:year |
1997
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pubmed:articleTitle |
Inhibition of nitric oxide synthase prevents magnesium-free-induced epileptiform activity in guinea-pig piriform cortex neurones in vitro.
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pubmed:affiliation |
Department of Pharmacology, The School of Pharmacy, London, UK.
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pubmed:publicationType |
Journal Article,
In Vitro
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