Linked Life Data

9109198

Source:http://linkedlifedata.com/resource/pubmed/id/9109198

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-6-12
pubmed:abstractText
To be effective, an immunocontraceptive vaccine should elicit strong, sustained antibody responses. Circulating antibodies may block the function of hormones and target some gamete antigens, but the most effective inhibition of fertilization will probably be achieved by antibodies in the reproductive tract. It may also be beneficial to administer vaccine antigens with strong adjuvants, such as cytokines, in order to achieve high specific antibody titres. In this review recent findings concerning the role of cytokines in the regulation of antibody responses, particularly at mucosae, are described and prospects for immunization for immune responses which may be important for fertility control are discussed. On the basis of these findings, a model system for the delivery of vaccine antigens to the immune system in vaccinia, fowlpox or DNA plasmid vectors along with type-2 cytokines, such as interleukin-4 (IL-4), IL-5 and IL-6, as B cell adjuvants is presented. Studies such as these in the areas of antigen delivery and enhancement of immune responses are aimed at providing new options for fertility control, particularly via oral vaccination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1031-3613
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-7
pubmed:dateRevised
2006-4-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Cytokine enhancement of immune responses important for immunocontraception.
pubmed:affiliation
Viral Engineering and Cytokine Research Group, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
pubmed:publicationType
Journal Article, Review