|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1997-5-2
|
|
pubmed:abstractText |
Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
pubmed-author:CascieriM AMA,
pubmed-author:FeighnerS DSD,
pubmed-author:HowardA DAD,
pubmed-author:McKeeK KKK,
pubmed-author:PalyhaO COC,
pubmed-author:ShiaoL LLL,
pubmed-author:SmithR GRG,
pubmed-author:SullivanK AKA,
pubmed-author:TanCC,
pubmed-author:Van Der PloegL HLH,
pubmed-author:WeinbergD HDH
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
405
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
285-90
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9108306-Amino Acid Sequence,
pubmed-meshheading:9108306-Animals,
pubmed-meshheading:9108306-Base Sequence,
pubmed-meshheading:9108306-Binding, Competitive,
pubmed-meshheading:9108306-Cloning, Molecular,
pubmed-meshheading:9108306-Gene Expression,
pubmed-meshheading:9108306-Molecular Sequence Data,
pubmed-meshheading:9108306-Multigene Family,
pubmed-meshheading:9108306-Rats,
pubmed-meshheading:9108306-Receptors, Galanin,
pubmed-meshheading:9108306-Receptors, Gastrointestinal Hormone,
pubmed-meshheading:9108306-Sequence Alignment,
pubmed-meshheading:9108306-Sequence Homology, Amino Acid,
pubmed-meshheading:9108306-Tissue Distribution
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Molecular cloning and characterization of a new receptor for galanin.
|
|
pubmed:affiliation |
Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA. howarda@merck.com
|
|
pubmed:publicationType |
Journal Article
|
