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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1997-5-22
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pubmed:abstractText |
HIV-1 infection of the central nervous system (CNS) frequently causes dementia and other neurological disorders. The mechanisms of CNS injury in HIV-1 infection are poorly understood. Apoptosis of neurons and astrocytes is induced by HIV-1 infection in vitro and in brain tissue from AIDS patients, but the apoptotic stimuli have not been identified. We report herein that HIV-1 infection of primary brain cultures induces the receptor tyrosine kinase protooncogene c-kit and that high levels of c-Kit expression are associated with astrocyte apoptosis. Overexpression of c-Kit in an astrocyte-derived cell line in the absence of HIV-1 induces rapid apoptotic death. The apoptotic mechanism requires the c-Kit tyrosine kinase domain. The mechanism of c-kit induction by HIV-1 involves transactivation of the c-kit promoter by the HIV-1 Nef protein. These studies demonstrate that c-Kit can induce astrocyte apoptosis and suggest that this mechanism may play a role in CNS injury caused by HIV-1 infection. We propose that c-Kit can serve dual functions as a growth factor receptor or apoptosis inducer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1354393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1377810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1384954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1404605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1433527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1631166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-1721869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-2448137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-2456920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-3277272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-3532930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7477729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7477730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7506248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7512958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7515099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7519782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7531500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7537428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7568162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7628010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7664345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7683154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7747806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7816645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7859737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7877652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-7884864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8108442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8145918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8145919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8254781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8377009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8503191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8651642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8774880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8891342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108086-8903316
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3954-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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