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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1997-5-22
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pubmed:abstractText |
We investigated the role of the T cell antigen receptor (TcR) in control of T cell migration in an in vitro system. We used T cells from transgenic mice bearing a TcR for the lysozyme peptide 48-62 bound to I-A(k) (3A9). T cells from the 3A9 TcR transgenic mice crawled on purified intercellular adhesion molecule-1 substrates, but strikingly, stopped upon interaction with the physiological ligand, i.e., the mouse I-A(k) with covalently attached hen egg white lysozyme peptide residues 48-62 complex. TcR-triggered stopping was reversible by treatment with adhesion-strengthening phorbol esters. The microtubule organizing center of stopped cells was positioned adjacent to the site of stable cell anchorage. Direct conversion of lymphocyte function associated-1 to the high-affinity conformation with antibodies also stopped T cells in a similar manner to antigen. Thus, physiological TcR engagement triggers a stop signal through lymphocyte function associated-1. We propose that the stop signal is an early and essential event in T cell activation that also will play an important role in control of T cell migration.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-1349320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-1402675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-1531629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-2115981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-2147199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-2477710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-2941079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-309887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3100481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-313569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3259335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3499312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3517218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3548771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-3876513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-4038710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-4115130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-4399170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-6418801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-689085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7017745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7213617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7535698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7697352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7761442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-7778885,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8095510,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8630728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8636222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8637599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8637857,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8757322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8786292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-8978608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-9050881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-9064327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9108078-932106
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3909-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
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pubmed:affiliation |
Center for Immunology and Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. dustin@pathbox.wustl.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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