Linked Life Data

9107406

Source:http://linkedlifedata.com/resource/pubmed/id/9107406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-6-23
pubmed:abstractText
The continuous replenishment of mature blood cells from multipotent stem cells proceeds under the influence of haemopoietic growth factors which clearly regulate both cell survival and proliferation. The extent to which these factors might influence lineage choice is still unclear, however, and it seems likely that resolution of this issue will require direct analysis of multipotent cells undergoing commitment rather than determination of their productivity in colony assays. Chromatin analysis of a multipotent progenitor cell line indicates that many of the genes relevant to alternative lineage fates are maintained in an accessible (primed) state prior to lineage commitment. Furthermore, multipotent cells have been found to co-express a number of lineage-restricted genes, suggesting that commitment proceeds as the consolidation of an existing programme. There are indications that the patterns of gene expression in multipotent progenitors change over time, raising the possibility of temporal priming towards different lineages. In multipotential cell lines, exogenous growth factors are necessary for survival, but not for lineage commitment, implying a largely supportive role in early progenitors. In contrast, recent work on primary bipotent granulocyte/ macrophage progenitors does demonstrate an inductive role for growth factors in these more lineage-restricted cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-14; discussion 14-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
How do stem cells decide what to do?
pubmed:affiliation
Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't