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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-4-25
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pubmed:abstractText |
Short-term depletion of plasma tryptophan has been shown to result in depressive relapse in patients with remission of major depression. Positron emission tomography and single photon emission computed tomography studies implicated the dorsolateral prefrontal cortex, orbitofrontal cortex, thalamus, and caudate nucleus in the pathogenesis of depression. The purpose of this study was to measure cerebral metabolic correlates of tryptophan depletion-induced depressive relapse.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-990X
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pubmed:author |
pubmed-author:BremnerJ DJD,
pubmed-author:BronenR ARA,
pubmed-author:CharneyD SDS,
pubmed-author:DeaPP,
pubmed-author:DuncanJJ,
pubmed-author:InnisR BRB,
pubmed-author:KrystalJ HJH,
pubmed-author:MalisonRR,
pubmed-author:MillerH LHL,
pubmed-author:NgC KCK,
pubmed-author:PriceL HLH,
pubmed-author:RiceAA,
pubmed-author:SalomonR MRM,
pubmed-author:SouferRR,
pubmed-author:StaibL HLH
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9107153-Antidepressive Agents,
pubmed-meshheading:9107153-Brain,
pubmed-meshheading:9107153-Deoxyglucose,
pubmed-meshheading:9107153-Depressive Disorder,
pubmed-meshheading:9107153-Double-Blind Method,
pubmed-meshheading:9107153-Fluorodeoxyglucose F18,
pubmed-meshheading:9107153-Glucose,
pubmed-meshheading:9107153-Humans,
pubmed-meshheading:9107153-Limbic System,
pubmed-meshheading:9107153-Placebos,
pubmed-meshheading:9107153-Prefrontal Cortex,
pubmed-meshheading:9107153-Psychiatric Status Rating Scales,
pubmed-meshheading:9107153-Recurrence,
pubmed-meshheading:9107153-Serotonin,
pubmed-meshheading:9107153-Thalamus,
pubmed-meshheading:9107153-Tomography, Emission-Computed,
pubmed-meshheading:9107153-Tryptophan
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pubmed:year |
1997
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pubmed:articleTitle |
Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse.
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pubmed:affiliation |
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial
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