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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-6-4
|
| pubmed:abstractText |
We studied erythropoiesis in 31 patients with vitamin B12 deficiency by measuring serum erythropoietin (s-Epo), serum transferrin receptor (s-TfR, taken as an index of total erythroid activity), reticulocyte count, and the reticulocyte maturation index (RMI). s-Epo and s-TfR were measured with commercial immunoassays, whereas reticulocyte count and RMI were determined by flow cytometry. s-Epo (123 +/- 196 U/L) and s-TfR (4.1 +/- 2 mg/L) levels were increased in patients with vitamin B12 deficiency. The absolute reticulocyte counts were decreased (29 +/- 18 x 10(9)/L) with a relative increase in the most immature fractions (RMI: 29.6 +/- 18%). A significant negative relationship was found between s-Epo and Hb level (r = -0.65, p < 0.0001). On the average, however, s-Epo was inappropriately low for the degree of anemia, since the observed/predicted (O/P) s-Epo ratio was 0.80 +/- 0.28 in vitamin B12 deficiency vs 1.00 +/- 0.16 in a group of patients with iron deficiency anemia. It is concluded that at least a portion of patients with vitamin B12 deficiency have serum erythropoietin levels that are inappropriately low for the degree of anemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Erythropoietin,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0390-6078
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
82
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
67-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9107086-Adolescent,
pubmed-meshheading:9107086-Adult,
pubmed-meshheading:9107086-Aged,
pubmed-meshheading:9107086-Anemia, Hypochromic,
pubmed-meshheading:9107086-Anemia, Pernicious,
pubmed-meshheading:9107086-Creatinine,
pubmed-meshheading:9107086-Erythropoietin,
pubmed-meshheading:9107086-Female,
pubmed-meshheading:9107086-Ferritins,
pubmed-meshheading:9107086-Hemoglobins,
pubmed-meshheading:9107086-Humans,
pubmed-meshheading:9107086-Malabsorption Syndromes,
pubmed-meshheading:9107086-Male,
pubmed-meshheading:9107086-Middle Aged,
pubmed-meshheading:9107086-Postgastrectomy Syndromes,
pubmed-meshheading:9107086-Receptors, Transferrin,
pubmed-meshheading:9107086-Reticulocyte Count,
pubmed-meshheading:9107086-Vitamin B 12 Deficiency
|
| pubmed:articleTitle |
Serum erythropoietin and erythroid activity in vitamin B12 deficiency.
|
| pubmed:affiliation |
Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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| pubmed:publicationType |
Journal Article
|