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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1997-4-29
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pubmed:abstractText |
Ornithine decarboxylase (ODC) plays a pivotal role in the synthesis of polyamines, a group of chemical compounds that are essential for cell growth. Recent reports have shown that ODC overexpression may be involved in malignant transformation of immortalized NIH 3T3 cells. We have demonstrated that ODC-overproducing mouse breast cancer cells are more invasive in vitro than control cells. However, little information is available concerning the relationship between ODC overexpression, tumor invasion, and metastasis and the signal transduction pathways involved in ODC-induced transformation and invasion.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
16
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9106645-Animals,
pubmed-meshheading:9106645-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9106645-Cell Transformation, Neoplastic,
pubmed-meshheading:9106645-Female,
pubmed-meshheading:9106645-Fibroblasts,
pubmed-meshheading:9106645-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9106645-Mammary Neoplasms, Experimental,
pubmed-meshheading:9106645-Mice,
pubmed-meshheading:9106645-Neoplasm Invasiveness,
pubmed-meshheading:9106645-Ornithine Decarboxylase,
pubmed-meshheading:9106645-Phenotype,
pubmed-meshheading:9106645-Transfection,
pubmed-meshheading:9106645-Up-Regulation
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pubmed:year |
1997
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pubmed:articleTitle |
Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.
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pubmed:affiliation |
Department of Physiological Chemistry and Nutrition, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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