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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-7-7
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pubmed:abstractText |
The influence of the new calcium antagonist mibefradil (CAS 116666-63-8, Ro 405967) on calcium influx into rabbit smooth muscle cells (VSMC) was studied. Angiotensin II-stimulated divalent cations entry was blocked by mibefradil at micromolar concentrations (1-10 mumol/l). In the same range of concentrations, the antagonist depressed capacitative calcium influx evoked by thapsigargin- and 2,5-di-tert-butylhydroquinone (BHQ)-dependent depletion of internal depots. The ability to block the receptor-mediated pathway of calcium current into VSMC may explain in part the difference between the mode of pharmacological action of mibefradil as compared to other calcium antagonists.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,5-di-tert-butylhydroquinone,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Transporting ATPases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Fura-2,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Mibefradil,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-4172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9105541-Angiotensin II,
pubmed-meshheading:9105541-Animals,
pubmed-meshheading:9105541-Benzimidazoles,
pubmed-meshheading:9105541-Blood Platelets,
pubmed-meshheading:9105541-Calcium,
pubmed-meshheading:9105541-Calcium Channel Blockers,
pubmed-meshheading:9105541-Calcium-Transporting ATPases,
pubmed-meshheading:9105541-Cell Membrane,
pubmed-meshheading:9105541-Enzyme Inhibitors,
pubmed-meshheading:9105541-Fluorescent Dyes,
pubmed-meshheading:9105541-Fura-2,
pubmed-meshheading:9105541-Hydroquinones,
pubmed-meshheading:9105541-Membrane Potentials,
pubmed-meshheading:9105541-Mibefradil,
pubmed-meshheading:9105541-Muscle, Smooth, Vascular,
pubmed-meshheading:9105541-Rabbits,
pubmed-meshheading:9105541-Tetrahydronaphthalenes,
pubmed-meshheading:9105541-Thapsigargin,
pubmed-meshheading:9105541-Vasoconstrictor Agents
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pubmed:year |
1997
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pubmed:articleTitle |
Influence of mibefradil on Ca2+ influx induced by vasoactive hormones or depletion of intracellular calcium stores.
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pubmed:affiliation |
Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
In Vitro
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