Linked Life Data

9103703

Source:http://linkedlifedata.com/resource/pubmed/id/9103703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-6-4
pubmed:abstractText
Local cerebral blood flow (LCBF) was measured using the [14C] iodoantipyrine method in 76 discrete brain regions in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) of 4 months old (young-adult) and 16-17 months old (aged). Compared with the young-adult WKY, in both the young-adult and aged SHR, LCBF was reduced in scattered brain regions, in more wide-spread regions in the aged SHR, while LCBF was not significantly decreased in the aged WKY. The results indicate that, firstly, cerebral hypoperfusion is already established at the age of 4 months by persistent hypertension in SHR, but age-related decline of LCBF thereafter is not remarkable, and secondly, cerebral perfusion is preserved in normotensive WKY even in their senescence. Combined with the present results and the previous study that local cerebral glucose utilization (LCGU) reduced in the aged groups of WKY and SHR in scattered brain regions, more intensively and more extensively in the aged SHR, but did not in the young-adult SHR, the followings are suggested: 1) in the young-adult SHR, LCBF is decreased but brain metabolism is preserved in a state of misery perfusion, 2) in the normotensive aged WKY, LCBF is preserved but brain metabolism is reduced implying "primary hypometabolism during senescence", and 3) in the aged SHR, LCBF is decreased and brain metabolism is more severely reduced, probably resulting from a combination of the primary hypometabolism of the brain by aging and a secondary hypometabolism due to the long-standing hypertension related hypoperfusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0016-254X
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Decreased local cerebral blood flow in young and aged spontaneously hypertensive rats.
pubmed:affiliation
Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't