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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1977-11-30
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pubmed:abstractText |
A disabling osteomalacic syndrome seen only during regular hemodialysis is described. Its features include skeletal fractures, pain, suppression of pre-existing hyperparathyroidism, and failure to improve with any of the vitamin-D metabolites. Phosphate depletion may be an important etiological factor but this could not explain all cases. A trial with phosphate-enriched dialysate and 1alphaOHD3 resulted in sustained clinical improvement in 54% of the patients and healing of fractures in 33%. Other etiological factors independent of 1,25(OH)2D3 deficiency and phosphate depletion must be considered. Current, indirect evidence suggests that accumulation of water toxins including aluminium may be important.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0066-0078
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
376-84
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:910360-Adolescent,
pubmed-meshheading:910360-Adult,
pubmed-meshheading:910360-Female,
pubmed-meshheading:910360-Humans,
pubmed-meshheading:910360-Male,
pubmed-meshheading:910360-Middle Aged,
pubmed-meshheading:910360-Osteomalacia,
pubmed-meshheading:910360-Parathyroid Hormone,
pubmed-meshheading:910360-Phosphates,
pubmed-meshheading:910360-Renal Dialysis,
pubmed-meshheading:910360-Vitamin D
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pubmed:year |
1977
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pubmed:articleTitle |
The need and use of a phosphate-enriched dialysate during regular hemodialysis.
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pubmed:publicationType |
Journal Article
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