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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-5-6
|
| pubmed:abstractText |
Depressed cell-mediated immunity and decreased insulin-like growth factor I (IGF-I) are observed in malnourished humans. To study the interaction among nutrition, IGF-I, and cytokines, healthy volunteers (six men and four women, aged 21-38 yr, weighing 93-124% of ideal body weight) were subjected to a 7-day fast (mineral water only). Fasting steadily decreased serum IGF-I from 247 +/- 29 (prefast) to 87 +/- 10 ng/mL (postfast; P < 0.0001), total T cells (CD3+) from 1499 +/- 68 to 1308 +/- 70 x 10(9) (P < 0.0001), and T helper cells (CD4+) from 997 +/- 62 to 856 +/- 55 x 10(9) (P < 0.001). Peripheral blood mononuclear cells were isolated and cultured in serum-free RPMI 1640 for 24 h. Fasting attenuated peripheral blood mononuclear cell production of interleukin-2 in response to various concentrations of phytohemagglutinin P [PHA-P; 347 +/- 48 (prefast) vs. 135 +/- 52 pg/mL (postfast) when challenged with 3 micrograms/mL PHA-P; P < 0.005 when comparing dose-response curves (1-100 micrograms/mL PHA-P)]. Although the approximately 3-fold suppression of interleukin-2 and IGF-I in subjects fasted for 1 week is not likely to affect immune function significantly, our results with this short term model of nutrient restriction provide insight into possible mechanisms for immune suppression in chronic starvation.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/phytohemagglutinin-P
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
82
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1177-80
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9100592-Acute Disease,
pubmed-meshheading:9100592-Adult,
pubmed-meshheading:9100592-Cells, Cultured,
pubmed-meshheading:9100592-Cytokines,
pubmed-meshheading:9100592-Dose-Response Relationship, Drug,
pubmed-meshheading:9100592-Fasting,
pubmed-meshheading:9100592-Female,
pubmed-meshheading:9100592-Humans,
pubmed-meshheading:9100592-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:9100592-Insulin-Like Growth Factor I,
pubmed-meshheading:9100592-Interleukin-2,
pubmed-meshheading:9100592-Lipopolysaccharides,
pubmed-meshheading:9100592-Male,
pubmed-meshheading:9100592-Monocytes,
pubmed-meshheading:9100592-Osmolar Concentration,
pubmed-meshheading:9100592-Phytohemagglutinins,
pubmed-meshheading:9100592-Starvation,
pubmed-meshheading:9100592-T-Lymphocyte Subsets,
pubmed-meshheading:9100592-Time Factors
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Decreased interleukin-2 production from cultured peripheral blood mononuclear cells in human acute starvation.
|
| pubmed:affiliation |
Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA. lars.savendahl@histocel.umu.se
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|