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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-5-20
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pubmed:databankReference |
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pubmed:abstractText |
A gene encoding the alpha-tubulin of Candida albicans has been cloned and characterized. Nucleotide sequence analysis reveals the presence of an intron within the structural gene and predicts the synthesis of a polypeptide of 448 amino acid residues. Comparison of nucleotide and amino acid sequences with the Saccharomyces cerevisiae alpha-tubulin encoding genes shows a 75% homology and about 92% similarity respectively. In contrast to S. cerevisiae, C. albicans appears to possess only one gene for alpha-tubulin which is able to functionally complement a S. cerevisiae cold-sensitive tub1 mutant.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9099874-Amino Acid Sequence,
pubmed-meshheading:9099874-Base Sequence,
pubmed-meshheading:9099874-Candida albicans,
pubmed-meshheading:9099874-DNA, Fungal,
pubmed-meshheading:9099874-Fungal Proteins,
pubmed-meshheading:9099874-Gene Dosage,
pubmed-meshheading:9099874-Genes, Fungal,
pubmed-meshheading:9099874-Genetic Complementation Test,
pubmed-meshheading:9099874-Humans,
pubmed-meshheading:9099874-Molecular Sequence Data,
pubmed-meshheading:9099874-Mutation,
pubmed-meshheading:9099874-Saccharomyces cerevisiae,
pubmed-meshheading:9099874-Sequence Homology, Amino Acid,
pubmed-meshheading:9099874-Tubulin
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pubmed:year |
1997
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pubmed:articleTitle |
Isolation and characterization of a gene encoding alpha-tubulin from Candida albicans.
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pubmed:affiliation |
Department of Animal Biology and Genetics, University of Florence, Firenze, Italy.
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pubmed:publicationType |
Journal Article
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