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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-6-9
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pubmed:abstractText |
Fluoro-Jade is an anionic fluorochrome capable of selectively staining degenerating neurons in brain slices. The histochemical application of Fluoro-Jade results in a simple, sensitive and reliable method for staining degenerating neurons and their processes. The technique will detect neuronal degeneration resulting from exposure to a variety of neurotoxic insults. Fluoro-Jade can be combined with other fluorescent methodologies including immunofluorescence, fluorescent axonal tract tracing, and fluorescent Nissl counterstaining. Compared to conventional methodologies, Fluoro-Jade is a more sensitive and definitive marker of neuronal degeneration than hematoxylin and eosin (H&E) or Nissl type stains, while being comparably sensitive yet considerably simpler and more reliable than suppressed silver techniques.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/3-nitropropionic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Eosine Yellowish-(YS),
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Hallucinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Hematoxylin,
http://linkedlifedata.com/resource/pubmed/chemical/Ibogaine,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Metals,
http://linkedlifedata.com/resource/pubmed/chemical/Nitro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phencyclidine,
http://linkedlifedata.com/resource/pubmed/chemical/Propionic Acids
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
751
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9098566-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:9098566-Animals,
pubmed-meshheading:9098566-Antihypertensive Agents,
pubmed-meshheading:9098566-Axons,
pubmed-meshheading:9098566-Dizocilpine Maleate,
pubmed-meshheading:9098566-Dopamine Agents,
pubmed-meshheading:9098566-Eosine Yellowish-(YS),
pubmed-meshheading:9098566-Excitatory Amino Acid Agonists,
pubmed-meshheading:9098566-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9098566-Eye Enucleation,
pubmed-meshheading:9098566-Fluorescent Antibody Technique,
pubmed-meshheading:9098566-Fluorescent Dyes,
pubmed-meshheading:9098566-Hallucinogens,
pubmed-meshheading:9098566-Hematoxylin,
pubmed-meshheading:9098566-Ibogaine,
pubmed-meshheading:9098566-Kainic Acid,
pubmed-meshheading:9098566-Male,
pubmed-meshheading:9098566-Metals,
pubmed-meshheading:9098566-Nerve Degeneration,
pubmed-meshheading:9098566-Nissl Bodies,
pubmed-meshheading:9098566-Nitro Compounds,
pubmed-meshheading:9098566-Phencyclidine,
pubmed-meshheading:9098566-Propionic Acids,
pubmed-meshheading:9098566-Rats,
pubmed-meshheading:9098566-Rats, Sprague-Dawley,
pubmed-meshheading:9098566-Sensitivity and Specificity,
pubmed-meshheading:9098566-Silver Staining,
pubmed-meshheading:9098566-Stereotaxic Techniques
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pubmed:year |
1997
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pubmed:articleTitle |
Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration.
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pubmed:affiliation |
Division of Neurotoxicology, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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