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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-5-1
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pubmed:abstractText |
A series of single alanine substituted analogs of amyloid beta peptide (25-35) were tested for their ability to activate the phospholipases of cultured LA-N-2 cells. Substitution of alanine for the amino acids 29-34 prevented the activation of phospholipases A2 and D. In addition substitution of alanine at 28 prevented phospholipase D but not phospholipase A2 activation. All the alanine substitutions, except for positions 33 and 35, blunted phospholipase C activations. There were no activations by scrambled amyloid beta peptide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
405
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9094425-Alanine,
pubmed-meshheading:9094425-Amyloid beta-Peptides,
pubmed-meshheading:9094425-Enzyme Activation,
pubmed-meshheading:9094425-Humans,
pubmed-meshheading:9094425-Peptide Fragments,
pubmed-meshheading:9094425-Phospholipase D,
pubmed-meshheading:9094425-Phospholipases A,
pubmed-meshheading:9094425-Phospholipases A2,
pubmed-meshheading:9094425-Structure-Activity Relationship,
pubmed-meshheading:9094425-Tumor Cells, Cultured,
pubmed-meshheading:9094425-Type C Phospholipases
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pubmed:year |
1997
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pubmed:articleTitle |
Activation of LA-N-2 cell phospholipases by single alanine substitution analogs of amyloid beta peptide (25-35).
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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