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pubmed:abstractText |
Cyclins and their catalytic partners, the cyclin-dependent kinases (Cdks), function as key regulators of the eukaryotic cell cycle. Specific cyclin-Cdk complexes are active at successive stages during the cell cycle and control cell-cycle progression by phosphorylating specific target proteins, most of which have not yet been identified. B-Myb, a conserved member of the Myb oncoprotein family, is a sequence-specific DNA-binding protein expressed in virtually all proliferating mammalian cells. Increasing evidence suggests that B-Myb plays an important role during the late G1 and early S phases of the cell cycle. In this study, we have examined the regulation of B-Myb activity by cyclin-Cdks.
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pubmed:affiliation |
Hans-Spemann-Laborataory, Max-Planck-Institute for Immunobiology, Stübeweg 51, D-79108, Fakultät für Biologie, Universität Freiburg, D-79104, Freiburg, Germany,
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