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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-6-11
pubmed:abstractText
A simple four-compartment model for magnetization transfer was used to obtain theoretical expressions for the relationship between regional cerebral blood flow and delta M, the change in longitudinal magnetization of brain water spins when arterial water spins are perturbed. The theoretical relationship can be written in two forms, depending on the approach used to normalize delta M. Using the first approach, the calculation of cerebral blood flow requires a knowledge of R1(omega 1, delta omega), the longitudinal relaxation rate observed in the presence of continuous off-resonance RF irradiation. Using the second approach, the calculation of cerebral blood flow requires a knowledge of R1(omega 1, delta omega), where R1(omega 1, delta omega) is given by the product of R1(omega 1, delta omega) and the fractional steady-state longitudinal water magnetization in the presence of off-resonance RF irradiation. If the off-resonance RF irradiation used for arterial tagging does not produce appreciable magnetization transfer effects, R1(omega 1, delta omega) can be approximated by the longitudinal relaxation rate measured in the absence of off-resonance RF irradiation, R1obs. Theoretical expressions obtained by using the four-component model for magnetization transfer are compared with equivalent expressions obtained by using two-compartment models.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
501-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of magnetization transfer on the measurement of cerebral blood flow using steady-state arterial spin tagging approaches: a theoretical investigation.
pubmed:affiliation
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892-1060, USA.
pubmed:publicationType
Journal Article, Comparative Study