Linked Life Data

9089277

Source:http://linkedlifedata.com/resource/pubmed/id/9089277

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-5-1
pubmed:databankReference
pubmed:abstractText
The peripheral membrane protein gephyrin is essential for the postsynaptic localization of the inhibitory glycine receptor and is thought to anchor the receptor complex to the subsynaptic cytoskeleton. Since gephyrin transcripts are also found in non-neuronal tissues, we analyzed the 5'-flanking region of the gephyrin gene to identify its promoter region. This region contains several SP1 consensus sites, which may account for the widespread expression of gephyrin mRNA. Indeed, reporter gene constructs encompassing at least the two SP1 consensus sites upstream from the transcription start site were efficiently transcribed in both a fibroblast and a neuronal cell line. Our data are consistent with the widespread expression of the gephyrin gene in most mammalian tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
405
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-40
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Analysis of the promoter region of the murine gephyrin gene.
pubmed:affiliation
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't