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pubmed-article:9088586pubmed:abstractTextDiuretic therapy is conventionally used to treat oedema in patients with hypoxic cor pulmonale. This condition is associated with activation of the renin angiotensin system (RAS) with elevated levels of angiotensin II (ANG II), a potent pulmonary pressor agent. We explored the hypothesis that RAS activation by diuretic therapy might therefore worsen hypoxic pulmonary vasoconstriction via the effects of ANG II on the pulmonary vascular bed.lld:pubmed
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pubmed-article:9088586pubmed:articleTitleEffects of frusemide and hypoxia on the pulmonary vascular bed in man.lld:pubmed
pubmed-article:9088586pubmed:affiliationDepartment of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, UK.lld:pubmed
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