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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-7-2
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pubmed:abstractText |
The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S 180 at 9q22.3, and very recently mutations of a candidate gene in this region--the human homolog of the Drosophila patched gene have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long-range map spanning approximately 5 Mb between the recombination-determined flanking markers. Six genes have been mapped to this interval.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1045-2257
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9087571-17-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:9087571-Animals,
pubmed-meshheading:9087571-Basal Cell Nevus Syndrome,
pubmed-meshheading:9087571-Chromosome Mapping,
pubmed-meshheading:9087571-Chromosomes, Artificial, Yeast,
pubmed-meshheading:9087571-Chromosomes, Human, Pair 9,
pubmed-meshheading:9087571-Drosophila,
pubmed-meshheading:9087571-Fructose-Bisphosphatase,
pubmed-meshheading:9087571-Genes, Insect,
pubmed-meshheading:9087571-Genetic Markers,
pubmed-meshheading:9087571-Humans,
pubmed-meshheading:9087571-Polymorphism, Genetic,
pubmed-meshheading:9087571-RNA Cap-Binding Proteins,
pubmed-meshheading:9087571-RNA-Binding Proteins,
pubmed-meshheading:9087571-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:9087571-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9087571-Sequence Tagged Sites
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pubmed:year |
1997
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pubmed:articleTitle |
Physical mapping of the 5 Mb D9S196-D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region.
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pubmed:affiliation |
Department of Dermatology, San Francisco General Hospital, California 94110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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