rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1997-6-5
|
pubmed:abstractText |
Aplastic anemia is a rare but severe complication of thionamide therapy. Although colony-stimulating factors have been used extensively in thionamide-induced agranulocytosis with good results, the same might not apply to aplastic anemia. We present a case of a patient with methimazole-induced aplastic anemia in which, as administration of recombinant human granulocyte-monocyte colony-stimulating factor for a week did not result in an increase in peripheral blood cell count, standard immunosuppressive treatment was needed to restore normal hematopoiesis. The clinical characteristics of this patient are compared with those of previous cases of thionamide-induced aplastic anemia, especially with the only other reported patient in which colony-stimulating factors were used.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1050-7256
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
67-70
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9086574-Anemia, Aplastic,
pubmed-meshheading:9086574-Antilymphocyte Serum,
pubmed-meshheading:9086574-Antithyroid Agents,
pubmed-meshheading:9086574-Blood Cell Count,
pubmed-meshheading:9086574-Bone Marrow,
pubmed-meshheading:9086574-Cyclosporine,
pubmed-meshheading:9086574-Female,
pubmed-meshheading:9086574-Glucocorticoids,
pubmed-meshheading:9086574-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9086574-Hemoglobins,
pubmed-meshheading:9086574-Humans,
pubmed-meshheading:9086574-Immunosuppressive Agents,
pubmed-meshheading:9086574-Methimazole,
pubmed-meshheading:9086574-Middle Aged,
pubmed-meshheading:9086574-Recombinant Proteins
|
pubmed:year |
1997
|
pubmed:articleTitle |
Methimazole-induced severe aplastic anemia: unsuccessful treatment with recombinant human granulocyte-monocyte colony-stimulating factor.
|
pubmed:affiliation |
Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain.
|
pubmed:publicationType |
Journal Article,
Case Reports
|