Linked Life Data

9086524

Source:http://linkedlifedata.com/resource/pubmed/id/9086524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-29
pubmed:abstractText
From a clinical perspective, prenatal transplantation has tremendous potential to broaden the current indications for reconstitution therapy and to offer a safe, efficacious, and cost-effective alternative to conventional postnatal BMT for many congenital hematopoietic diseases. Experimental work and limited clinical experience offer hope for the future. The primary experimental challenges will be to manipulate the biology of in utero HSC transplantation so that the approach will be safe and broadly applicable. This will require strategies to improve engraftment; use alternative sources of cells safely and effectively; and develop techniques for procurement, ex vivo expansion, and tissue banking of safe donor cells. The clinical challenges in the future will be to identify recipients most likely to benefit from the approach, and to define further the clinical and ethical guidelines for its application.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0889-8545
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-77
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Cellular therapy.
pubmed:affiliation
Children's Hospital of Philadelphia, Pennsylvania, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Case Reports, Research Support, Non-U.S. Gov't