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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-6-16
pubmed:abstractText
Diabetic nephropathy represents a major complication in patients with insulin-dependent diabetes mellitus (IDDM). Intervention trials using angiotensin-converting enzyme (ACE) inhibitors have pointed towards the important pathogenetic role of the renin-angiotensin system. Recently an insertion/ deletion (I/D) polymorphism for the gene encoding the ACE has been described, the deletion type being associated with higher plasma ACE levels. As the intrarenal renin-angiotensin system might also be activated in this setting, we determined the ACE genotype together with other risk factors for the development of diabetic nephropathy in 122 patients with IDDM from a single centre with (n = 63) and without (n = 59) nephropathy. Long-term glycaemic control was evaluated using mean HbA1c values from the last 10 years. The two patient group were comparable with regard to duration of diabetes and glycaemic control as assessed by current HbA1c values. However, mean long-term HbA1c values were significantly higher in patients with diabetic nephropathy as was systemic blood pressure. The DD genotype was more prevalent in patients with renal disease. In the subgroup of patients who had had diabetes for more than 20 years (n = 90), the DD genotype was even more frequent in patients with nephropathy, and blood pressure and long-term HbA1c values were also higher in patients with renal disease. Logistic regression analysis revealed long-term glycaemic control, blood pressure and the ACE genotype to be independent risk factors for the prevalence of diabetic nephropathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9084972-Blood Glucose, pubmed-meshheading:9084972-Blood Pressure, pubmed-meshheading:9084972-DNA Transposable Elements, pubmed-meshheading:9084972-Diabetes Mellitus, Type 1, pubmed-meshheading:9084972-Diabetic Angiopathies, pubmed-meshheading:9084972-Diabetic Nephropathies, pubmed-meshheading:9084972-Diabetic Retinopathy, pubmed-meshheading:9084972-Female, pubmed-meshheading:9084972-Genotype, pubmed-meshheading:9084972-Humans, pubmed-meshheading:9084972-Hypertension, pubmed-meshheading:9084972-Male, pubmed-meshheading:9084972-Middle Aged, pubmed-meshheading:9084972-Peptidyl-Dipeptidase A, pubmed-meshheading:9084972-Polymorphism, Genetic, pubmed-meshheading:9084972-Prevalence, pubmed-meshheading:9084972-Regression Analysis, pubmed-meshheading:9084972-Risk Factors, pubmed-meshheading:9084972-Sequence Deletion, pubmed-meshheading:9084972-Time Factors
pubmed:year
1997
pubmed:articleTitle
Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control.
pubmed:affiliation
Department of Internal Medicine III, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't